升上大學後,她先後在實驗室及符合「優良製造規範」(Good Manufacturing Practice ,簡稱GMP)的廠房實習,堅定了她對科研進路的決心。為了探索跨學科的知識,她還副修了有關永續城市、文化與地球的課程,她說:「作為學生,我們不應只專注於生命科學,還要培養全球視野——畢竟科學發展影響著整個世界。」
歌禮已於近期完成其評估口服小分子GLP-1受體(GLP-1R)激動劑ASC30治療肥胖症的13周II期研究(NCT07002905)。該研究在美國多個中心開展,共入組125例肥胖受試者或伴有至少一種體重相關合併症的超重受試者。在第13周的主要終點上,每日一次20毫克、40毫克和60毫克ASC30片分別實現了5.4%、7.0%和7.7%的經安慰劑校正後平均體重下降,體重下降具有統計學顯著性、臨床意義且呈劑量依賴性。未觀察到減重平台期。每週滴定直至目標劑量的ASC30的嘔吐發生率約為已公佈的每週滴定的orforglipron中觀察到的嘔吐發生率的一半。每週滴定的ASC30的胃腸道耐受性與已公佈的orforglipron在III期ATTAIN-1研究中每四周滴定(titrated every four weeks)的結果相當。在ASC30用於治療肥胖或超重的II期研究中,因不良事件導致的總體停藥率為4.8%。
歌禮製藥有限公司是一家全價值鏈整合型生物技術公司,聚焦有望成為治療代謝疾病同類最佳(best-in-class)和同類首創(first-in-class)藥物的開發和商業化。利用公司專有的基於結構的AI輔助藥物發現(Artificial Intelligence-Assisted Structure-Based Drug Discovery,AISBDD)、超長效藥物開發平台(Ultra-Long-Acting Platform,ULAP)技術以及口服多肽遞送增強技術(Peptide Oral Transport ENhancement Technology,POTENT),歌禮已自主研發多款小分子和多肽候選藥物,包括其核心項目ASC30,一款在研小分子GLP-1R激動劑,既可每日一次口服也可每月一次至每季度一次皮下注射作為減重治療療法和減重維持療法,用於長期體重管理;ASC36,一款每月一次皮下注射胰澱素受體激動劑多肽,ASC35,一款每月一次皮下注射GLP-1R/GIPR雙靶點激動劑多肽,ASC37,一款口服GLP-1R/GIPR/GCGR三靶點激動劑多肽,用於長期體重管理。歌禮已在香港聯交所上市(1672.HK)。
【Lai傳媒、記者爆料網/王傳文/綜合報導】好萊塢影帝湯米李瓊斯(Tommy Lee Jones)因主演《MIB星際戰警》系列電影紅遍全球,未料美國時間1日凌晨驚傳噩耗,他的34歲女兒維多莉亞瓊斯(Victoria Jones)被發現陳屍飯店房間內,消息震撼外界。警方調查多日後指出,初步研判死因疑與用藥過量有關,事發當晚的報案通話內容也隨之曝光。
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